Amidst prevailing healthcare challenges, a dynamic solution emerges, fusing knowledge graph technology, clinical trials optimization, dataspace integration, and AI innovation. This unified approach tackles issues like limited patient insights, suboptimal trial designs, and imprecise treatments. By interlinking diverse data through knowledge graphs, this method illuminates disease trends, therapeutic efficacies, and patient prognoses. AI techniques, especially machine learning, contribute predictive power by unveiling hidden patterns for accurate diagnostics, prognostics, and personalized treatments. This multidisciplinary fusion transforms clinical trials, enhancing comprehensiveness and precision through real-world data analysis and subgroup identification. In reshaping healthcare, this proposition aims to accelerate treatment personalization, elevate therapeutic efficacy, and empower informed medical decisions, encompassing the essence of ’Advancing Healthcare through Innovation: Knowledge Graphs, Clinical Trials, Dataspace, and AI’.