In the pharmacogenomic and theranostic approach of treating melanoma, a continuous monitoring of the disease and the mutations associated with the disease is essential. Such a monitoring system has been designed and developed based upon the concept ‘One-shot learning’, a machine learning technique adapted to work with a relatively small number of training images. The samples have been exhaustively studied through genomics, epigenomics, metagenomics and environmental genomics, finding the genetic signature behind proneness of these attributes. The mutations CDK4, CDKN2A, BRAF and KIT have been included in the analysis. The prediction accuracy of the machine is found to substantially high suggesting the device for the theranostic and pharmacogenomic strategies of controlling melanoma. A Distributed Ledger Technology (DLT) based system has been proposed for real time data sharing, training and analysis enabling hospitals and research labs to communicate with each other and conduct a cost-effective diagnostic workflow.