A novel ultrasonic needle biopsy device has been developed, based on a traditional lead (Pb)-based piezoceramic material (PZT), to address the clinical need for improved accuracy of needle placement in ultrasound-guided biopsy. Worldwide, particularly in the EU, regulatory agencies have begun to restrict the use of Pb; an accumulative toxicant. Due to its 60% by weight Ph-content, PZT has been identified formally as a substance of very high concern (SVHC). However, it enjoys exemption from restrictions until 2021 due to the lack of suitable Pb-free alternatives, which need to be identified and qualified with urgency. Building on the recent advances in the field of Pb-free materials and to assess the feasibility of these materials in medical applications, this paper reports a version of the Active Needle Technologies' (ANT's) biopsy device developed using a commercially available Pb-free piezoceramic material, PIC700. In doing so, the paper also draws a performance-based comparison between PIC700 and conventional piezoceramic, PIC181 (PZT-8), based devices.