The Application of Perlite/Cobalt Oxide/Reduced Graphene Oxide (PC-rGO)/Metal Organic Framework (MOF) Composite as Electrode Modifier for Direct Sensing of Anticancer Drug Idarubicin
- Resource Type
- Periodical
- Authors
- Dehdashtian, S.; Hashemi, B.; chegeni, m.; Aeenmehr, A.
- Source
- IEEE Sensors Journal IEEE Sensors J. Sensors Journal, IEEE. 19(24):11739-11745 Dec, 2019
- Subject
- Signal Processing and Analysis
Communication, Networking and Broadcast Technologies
Components, Circuits, Devices and Systems
Robotics and Control Systems
Sensors
Graphene
Electrodes
Conductivity
Scanning electron microscopy
Chemical sensors
Electric potential
Perlite@CoO@rGO (PC-rGO) nanocomposite
metal-organic framework MOF-199
electrochemical sensing
- Language
- ISSN
- 1530-437X
1558-1748
2379-9153
This article shows the voltammetric sensing of idarubicin (ID) using an electrochemical sensor modified by a composite (PC-rGO/MOF-199) consisted of perlite/cobalt oxide/reduced graphene oxide (perlite@CoO@rGO (PC-rGO)) nanocomposite and metal-organic framework MOF-199 (Cu). For the fabrication of the desired sensor (PC-rGO/MOF-199/CPE), the synthesized PC-rGO and MOF-199 were applied as modifier in the body of the carbon paste electrode (CPE). The most important factors that can be effective on the performance of the sensor were surveyed. Differential pulse voltammetry (DPV) was applied for recording the calibration curve. The sensor has a linear response over the 5–1000 nM ID concentration range and a 1.5 nM limit of detection (at an S/N ratio of 3). In addition, this sensor is a beneficial sensor for the determination of ID in the real samples.