Initiating explosive device is the key component of weapon system. Its safety performance is directly related to the normal play of weapons, which is determined by design and implemented by production. There is a high demanding for the safety performance of initiating explosive device both in domestic and abroad. Research on the safety response rule of initiating explosive device has important actual significance. In this paper, using logistic sensitivity distribution function model to evaluate the safety response rule of initiating explosive device. Based on VC + + programming, design an analysis software of safety response rule which could draw the responsivity curves to obtain the safety response rule of initiating explosive device. Through the verification of the actual experiment data, evaluation result of the analysis software is effective and in line with the experimental data.