The large-scale offshore wind farms (OWFs) penetrating into the power system has significantly changed the inertia distribution. The spatial-temporal characteristic of inertia leads to spatial frequency dynamics. Although the OWFs could provide inertial support to compensate the weak inertial area though virtual inertial control technology. While the typhoon attack happens, the OWFs should operate under typhoon mode and even shut down. However, the spatial-temporal inertia cannot be described from the perspective of the center of inertia, which will cause frequency security problem in the weak inertial area. Therefore, this paper focuses on the inertia distribution and analysis the frequency response results with different unit schedules. Then, a novel spatial-temporal inertia oriented operation scheduling strategy is proposed to guarantee the frequency security of the total power system. Various cases are simulated to verified the effectiveness of the proposed scheduling strategy.