As a consequence of the Covid-19 outbreak, students are required to stay at home to prevent the virus from spreading. This has resulted in a quick acceptance of online learning, as students and faculty cannot participate in in-class activities. This study examines the determinants affecting E-Learning uptake in Oman during the Covid-19 outbreak, using 223 student responses and structural equation modeling (SEM). Four hypotheses were supported, while two were rejected. Specifically, perceived ease of use, perceived usefulness, and institutional support affect behavioral intention to adopt E-Learning. However, infrastructure support and privacy risk, on the other hand, were not. Thus, this research serves as a springboard for higher education officials to increase the use of E-Learning and adjust to student hurdles for students to comprehend and effectively use the system.