An Analog VLSI Stimulation and Recording System for Extracelluar Interfacing
- Resource Type
- Conference
- Authors
- Blum, R.A.; Ross, J.D.; Brown, E.A.; DeWeerth, S.P.
- Source
- Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005. Neural Engineering, 2005. Conference Proceedings. 2nd International IEEE EMBS Conference on. :381-384 2005
- Subject
- Computing and Processing
Components, Circuits, Devices and Systems
Signal Processing and Analysis
Very large scale integration
Electrodes
Circuits
Extracellular
Voltage
Spatial resolution
Laboratories
Neural engineering
In vitro
Scalability
- Language
- ISSN
- 1948-3546
1948-3554
This paper presents an analog VLSI system for extracellular interfacing to in vitro neural cultures on multielectrode arrays (MEAs). The design offers significant advantages: scalability to large numbers of electrodes, experimental flexibility in stimulation patterns, and suppression of stimulus artifacts. The paper includes experimental data demonstrating the performance of the recording system. Through the use of artifact suppression circuitry, the system reduces the duration of stimulus artifacts to < 2 ms. This reduction is effective for the stimulation electrode as well as neighboring electrodes