Neural sensing and muscle stimulation have been the subject of several studies for decades. The clinical studies in the literature employ surgically implanted electrodes to record peripheral neural signals, stimulate the muscle tissues or bridge the proximal end of the injured peripheral nerve with the respective muscle. This is achieved by applying an electrical current with certain wave shapes. Conventional implantable electrodes are based on metals micro-wires (microelectrode arrays) mostly made of Platinum. To-date, these implanted microelectrodes suffered from several drawbacks including; 1) damage to the soft tissue, and 2) degradation over time leading to poor electrochemical properties and high interfacial impedance. A more practical electrode should be flexible, possess low interfacial impedance, selective for specific neural locations, and durable to avoid any tissue inflammation. This work aims at developing novel, low cost, flexible and bio-compatible implantable electrodes based on silicone and titanium dioxide (TiO 2 ). The fabricated electrodes were evaluated for their impedance and electrical conductivity using Electrochemical Impedance Spectroscopy (EIS). The preliminary experimental results showed an impedance of 24 kO at 1 kHz frequency. These results are promising and comparable to the ones in the literature such as the chromium-silver-chromium (Cr-Ag-Cr) electrodes [1] and Au electrodes [2].