Reliable two-way communication with the nervous system is one of the biggest challenges in the field of neural engineering. Many problems have prevented us to achieve this goal mostly involving the mechanical, biological and electrical interface between neural tissue and the man-made electrodes. Significant results have been achieved to interface with the brain directly and the current research is very promising. Another approach to gain information from the nervous system is to tap into the input to and output from the brain: the peripheral nervous system (PNS). This approach could be less invasive but has its own set of problems. In this presentation, I will review some of the various approaches, challenges and solutions to interfacing with the PNS.