Correlation analysis of Egr3, IL-6, TNF-α and the severity of coronary heart disease
- Resource Type
- article
- Authors
- Wang Siqing, Zumureti·Abudukeyimu, Li Xia
- Source
- Xin yixue, Vol 54, Iss 12, Pp 884-888 (2023)
- Subject
- early growth factor 3
coronary heart disease
interleukin-6
tumor necrosis factor-α
inflammation
Medicine
- Language
- Chinese
- ISSN
- 0253-9802
68545940
Objective To investigate the correlation between early growth response factor 3(Egr3), pro-inflammatory cytokines IL-6 and TNF-α and coronary atherosclerotic heart disease (CHD). Methods A total of 138 patients with confirmed CHD were collected, all of whom underwent coronary angiography and were divided into 2 groups based on the results of coronary angiography and Gensini score, including 66 patients in the mild stenosis group and 72 patients in the severe stenosis group, and 47 subjects with normal coronary angiography results were selected as the control group. Serum levels of Egr3, IL-6 and TNF-α were detected by ELISA. The general clinical data of the subjects were collected, and the differences of Egr3, IL-6 and TNF-α levels among all groups were compared to explore the relationship between the levels of EGR3 and Gensini scores. Results The serum levels of Egr3 and IL-6 in severe stenosis group were higher than those in control group and mild stenosis group, and the level of TNF-α in severe stenosis group was higher than that in control group, with statistical significance (all P < 0.05). The subject operation characteristic (ROC) curve showed that the area under the curve (AUC) of Egr3, IL-6 and TNF-α were 0.769, 0.784 and 0.565, respectively, and Egr3 had a good predictive value for CHD. Conclusion Egr3, IL-6 and TNF-α are highly expressed in CHD patients, and Egr3 can be used as an indicator to judge the severity of CHD patients.