Developments in Antibiotic-Eluting Scaffolds for the Treatment of Osteomyelitis
- Resource Type
- article
- Authors
- Harry Kyriacou; Achi Kamaraj; Wasim S. Khan
- Source
- Applied Sciences, Vol 10, Iss 7, p 2244 (2020)
- Subject
- antibiotic
scaffold
bone substitute
bone graft
osteomyelitis
orthopaedics
Technology
Engineering (General). Civil engineering (General)
TA1-2040
Biology (General)
QH301-705.5
Physics
QC1-999
Chemistry
QD1-999
- Language
- English
- ISSN
- 2076-3417
Osteomyelitis is a devasting disease caused by the infection of bone tissue and is associated with significant morbidity and mortality. It is treated with antibiotic therapy and surgical debridement. A high dose of systemic antibiotics is often required due to poor bone penetration and this is often associated with unacceptable side-effects. To overcome this; local; implantable antibiotic carriers such as polymethyl methacrylate have been developed. However; this is a non-biodegradable material that requires a second surgery to be removed. As a result; attention has shifted to new antibiotic-eluting scaffolds which can be created with a range of unique properties. The purpose of this review is to assess the level of evidence that exists for these novel local treatments. Although this field is still developing; these strategies seem promising and provide hope for the future treatment of chronic osteomyelitis.