Neuroinflammation, defined as an inflammatory response mediated by central nervous system astrocyte, Microglia and endothelial cells, disrupts homeostasis and is typical of many Neurodegeneration. The DA receptor family is mainly expressed in Microglia, and microglia-induced neuroinflammation is an important pathogenesis of Neurodegeneration, this article reviews the pathogenesis and treatment of neuroinflammation.