Effects of Panax quinquefolius L.-Acorus Tatarinowii on Cognitive Deficits and Brain Morphology of Type 1 Diabetic Rats
- Resource Type
- article
- Authors
- ZHOU You; YANG Yang; SONG Li-qiang; BI Tian-tian; WANG Yue; ZHAO Ying
- Source
- Chinese Journal of Magnetic Resonance, Vol 37, Iss 03, Pp 332-348 (2020)
- Subject
- magnetic resonance imaging (mri)
panax quinquefolius l.-acorus tatarinowii
diabetes mellitus
cognitive decline
learning and memory behaviors
Electricity and magnetism
QC501-766
- Language
- Chinese
- ISSN
- 20192738
1000-4556
This study explored the effects of Panax quinquefolius L.-Acorus Tatarinowii (X-S) on learning and memory behaviors and related brain regions in rats with diabetes-associated cognitive decline (DACD). Type 1 diabetes mellitus (DM) was induced by intraperitoneal injection of streptozotocin (STZ). The DM rats were randomly divided into the DM group and X-S group. Starting at day 7 after the STZ induction, X-S was administered once a day for 113 consecutive days. Morris water maze test was performed to screen the DM rats with and without cognitive impairment at 80 days after the STZ induction. The volume and concentration of gray matter and white matter in the whole brain were analyzed from magnetic resonance imaging (MRI) data acquired at day 120 after the STZ induction, with a region of interest (ROI)-based method and voxel-based morphometry (VBM). Hippocampal neurons were stained with hematoxylin and eosin (HE). The results of ROI-based analysis showed that:the volume of left temporal association cortex of the X-S rats decreased significantly (p