Based on e+e− annihilation data samples collected with the BESIII detector at the BEPCII collider at 13 center-of-mass energies from 4.008 to 4.600 GeV, measurements of the Born cross section of e+e−→pp¯π0 are performed. No significant resonant structure is observed in the measured energy dependence of the cross section. The upper limit on the Born cross section of e+e−→Y(4260)→pp¯π0 at the 90% C.L. is determined to be 0.01 pb. The upper limit on the ratio of the branching fractions B(Y(4260)→pp¯π0)B(Y(4260)→π+π−J/ψ) at the 90% C.L. is determined to be 0.02%. Keywords: Hadrons, Cross section measurements, Y(4260)