Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3
- Resource Type
- article
- Authors
- Ying Chen; Hongyan Li; Ke Wang; Yousheng Wang
- Source
- Molecules, Vol 28, Iss 12, p 4740 (2023)
- Subject
- organic anion transporter 3
drug–drug interactions
herb–drug interactions
natural active compounds
inhibitors
Organic chemistry
QD241-441
- Language
- English
- ISSN
- 1420-3049
Organic anion transporter 3 (OAT3) is predominantly expressed in the kidney and plays a vital role in drug clearance. Consequently, co-ingestion of two OAT3 substrates may alter the pharmacokinetics of the substrate. This review summarizes drug–drug interactions (DDIs) and herbal–drug interactions (HDIs) mediated by OAT3, and inhibitors of OAT3 in natural active compounds in the past decade. This provides a valuable reference for the combined use of substrate drugs/herbs for OAT3 in clinical practice in the future and for the screening of OAT3 inhibitors to avoid harmful interactions.