Molecular profiling of a high-grade squamous cell carcinoma arising from sinonasal inverted papilloma
- Resource Type
- article
- Authors
- Lonnie C. Saetern; Yihong Wang; Iole Ribizzi-Akhtar
- Source
- Otolaryngology Case Reports, Vol 27, Iss , Pp 100523- (2023)
- Subject
- Inverted papilloma
Squamous cell carcinoma of head and neck
Nasal polyps
Biomarkers
Otorhinolaryngology
RF1-547
- Language
- English
- ISSN
- 2468-5488
Inverted papillomas (IP) are benign neoplasms of the sinonasal cavity with a high rate of malignant transformation compared to simple nasal polyps, estimated in approximately 10% of cases. Recurrence of IP-associated squamous cell carcinoma (IP-SCC) following resection is relatively common, and treatment options are limited indicating a need for the introduction of tumor profiling in order to determine potential therapeutic targets. We present the case of a patient diagnosed with a highly invasive squamous cell carcinoma (SCC) arising from an inverted sinonasal papilloma. We aim to associate molecular analysis with beneficial treatment options for this patient diagnosed with a rare and aggressive cancer.