Background: Although patients with diabetes have common problems, their educational needs may differ, and they have the right to participate in planning and implementing individual or group healthcare programs. Because there are no proper care interventions for diabetic patients in Indonesia, this study evaluated the efficacy of a tailored care intervention program on some blood biochemical outcomes among Indonesian patients with diabetes. Methods: We conducted a randomized controlled trial (RCT) with a pre-test-post-test design. We recruited 163 diabetic patients referred to Moyo Hilir and Moyo Hulu primary healthcare facilities in Sumbawa City, Indonesia, from January to April 2021. The subjects were randomly assigned to either intervention (n=80) or control (n=83) groups. The intervention group received a tailored care intervention program with 7 elements implemented through four stages: 1) brief deductive teaching, 2) self-management assessment, 3) brainstorming and support group, and 4) Follow-up. The control group received routine education. The study data were collected at baseline and three months after the intervention. The outcome measures were blood glucose levels, cholesterol, triglyceride, and triglyceride glucose index. IBM SPSS software, version 20 was used for statistical analysis. The obtained data were analyzed by descriptive (frequency distributions, percentages, Mean±SD) and inferential statistics (Chi-square, independent t-test, and paired t-test). The significance level was set at P