Takayasu’s Arteritis and Crohn’s Disease in a Young Hispanic Female
- Resource Type
- article
- Authors
- Namrata Singh; Shireesh Saurabh; Irene J. Tan
- Source
- Case Reports in Rheumatology, Vol 2014 (2014)
- Subject
- Diseases of the musculoskeletal system
RC925-935
- Language
- English
- ISSN
- 2090-6889
2090-6897
Takayasu’s arteritis (TA) and Crohn’s disease (CD) are chronic inflammatory granulomatous disorders of undetermined etiology. TA is a large vessel vasculitis with a predilection for the aorta and its branches in young women of Asian descent; whereas CD has characteristic gastrointestinal manifestations more prevalent in young Caucasians. We describe a case of both diseases in a young Hispanic female, review the literature, and impart new insight on possible genetic linkage and the role of interleukin 12 B (IL-12B) as the common autoimmune mechanism and potential therapeutic target in this rare disease combination.