Takotsubo syndrome
- Resource Type
- article
- Authors
- Sanjiv Gupta; Madan Mohan Gupta
- Source
- Indian Heart Journal, Vol 70, Iss 1, Pp 165-174 (2018)
- Subject
- Left ventricular failure (LVF)
Regional wall motion abnormalities (RWMA)
Apical ballooning syndrome
Surgery
RD1-811
Diseases of the circulatory (Cardiovascular) system
RC666-701
- Language
- English
- ISSN
- 0019-4832
Takotsubo syndrome is a reversible acute heart failure frequently precipitated by an emotional or physical stress. The clinical presentation resembles acute coronary syndrome. Pathogenesis is complex and may involve brain-heart axis and neuro-hormonal stunning of the myocardium. Coronary angiography reveals normal epicardial arteries with no obstruction or spasm. NT-ProBNP maybe remarkably elevated. Regional wall motion akinesia (RWMA) of left ventricle extends beyond the territory of one coronary artery. Reduced left ventricle ejection fraction (LVEF) and RWMA recover in 6–12 weeks. Prognosis is generally good. Recent meta-analysis shows in-hospital mortality of 1–4.5% and recurrence rate of 5–10% during five year follow-up.