Objective: To analyse self-medication practice and its determinants among non-medical adult population of Rawalpindi. Study type, settings & duration: A cross-sectional descriptive study was carried out in Rawalpindi city from April to September 2022. Methodology: The 382 non-medical adults were enrolled through consecutive non-probability sampling. Self-administered structured questionnaire was used to gather the information pertinent to demographics of study subjects, distance from healthcare facility, access to medicines, ways of demanding medicine from pharmacist, reasons/ ailments for self-medication and source of information about drug. The data was analysed by using SPSS version 25.0 and Microsoft Excel 2016. Chi-square test was applied to determine the association of self-medication practice with education and socio-economic status. p < 0.05 was considered significant. Results: Out of 382 study subjects, most (54.2%) were females with mean age of 22.46±0.79 years. About 83% respondents were indulged in self-medication practice and 31.8% of them did self-medication due to quick relief from symptoms while 43.3% of the 65 persons did not indulge in self-medication due to fear of wrong use of drug. Low and middle social class had statistically significant association (p 0.05) with self-medication practice. Almost 61.8% of respondents were urban dwellers and 70% were students. About 40.14% were practicing self-medication in compliance with previous prescription. Conclusion: Female students are more indulged in self-medication practice for getting relief of their symptoms from previously prescribed medications.