Medical Subject Headings or simply MeSH are the controlled vocabularyused by Medline and other databases to classify and processthe information stored in them. When we search by the descriptors,more precise results are obtained, and the information will probablybe more appropriate to the interests of the users. The objective ofthe present work is to develop a guide, to create in the readersabilities for the search of information in Medline from MeSH. Step I:Selection of subject, words or significant phrases, and their equivalences in English. Step II: Search map elaboration. Step III: Search execution. Step IV: Outline and refine the strategy and state results. Critical evaluation. Bibliographical databases constitute one of the main sources of publications. The use of modern tools to search information in the health professions, requires the creation of a new culture, centered in interactive self-learning.