Immune-mediated chorea in a patient with kappa light-chain monoclonal gammopathy
- Resource Type
- article
- Authors
- Amrita J Gotur; Roopa Rajan; Rishi Dhawan; Ajay Garg
- Source
- Annals of Movement Disorders, Vol 3, Iss 2, Pp 112-114 (2020)
- Subject
- chorea
immune-mediated
monoclonal gammopathy of undetermined significance
peripheral neuropathy
Neurology. Diseases of the nervous system
RC346-429
- Language
- English
- ISSN
- 2590-3446
2590-3454
The objective of this paper was to report on a case of steroid-responsive chorea in a patient with κ light-chain monoclonal gammopathy. In addition to subacute-onset generalized chorea, evidence of peripheral neuropathy in this elderly gentleman led us to investigate for paraproteinemia. We treated the patient with intravenous steroids in view of elevated κ light-chain assay and bone marrow biopsy, suggestive of monoclonal gammopathy of undetermined significance. There was a remarkable improvement of paresthesias and chorea at 6 months follow-up with no evidence of evolution to malignancy at 1 year. Autoimmune chorea is a treatable condition if identified and treated timely.