The prognostic role of pre-treatment neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in esophageal squamous cell carcinoma treated with concurrent chemoradiotherapy
- Resource Type
- article
- Authors
- Qirong Man; Peishun Li; Jing Fan; Sen Yang; Chao Xing; Yunling Bai; Miaomiao Hu; Baohu wang; Kaixian Zhang
- Source
- BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
- Subject
- Esophageal squamous cell carcinoma
Neutrophil
Platelet
Lymphocyte
Concurrent chemoradiotherapy
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
- Language
- English
- ISSN
- 1471-2407
Abstract Purpose In this study, we retrospectively investigated the prognostic role of pre-treatment neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in esophageal squamous cell carcinoma patients (ESCC) treated with concurrent chemo-radiotherapy (CCRT). Methods We retrospectively analyzed the records of 338 patients with pathologically diagnosed esophageal squamous cell carcinoma that underwent concurrent chemo-radiotherapy from January 2013 to December 2017. Univariate and multivariate analyses were used to identify prognostic factors for progression free survival (PFS) and overall survival (OS). Results The result showed that the thresholds for NLR and PLR were 2.47 and 136.0 by receiver operating characteristic curve. High NLR and PLR were both associated with tumor length (P