Abstract Aim To investigate the quality of life in patients with endometrial carcinoma and provide theoretical basis for nursing care. Design In this study, 69 patients diagnosed with endometrial carcinoma from 2016–2018 were included in the cohort. Methods Sixty‐nine patients from our hospital who underwent endometrial cancer surgeries were selected. The SF‐36 was used to investigate and analyse the patients’ quality of life in the first, second and third months after their operations. Questionnaires were administered to analyse the factors affecting postoperative quality of life. Results Quality of life for the second and third months was obviously better than that for the first month after the operation (p