The present context was aimed to assess the impact of Mentha piperita L. stress at sub-inhibitory concentration on some key functional traits of coagulase-negative Staphylococcus hominis strain MANF2. Initially, the antibacterial activity of M. piperita L. leaves was determined against strain MANF2 and estimated its minimum inhibitory concentration (MIC) and sub-MIC values using standard protocols. Results showed promising antibacterial activity of M. piperita L. against strain MANF2 with MIC and sub-MIC values of 25 and 12.5%, respectively. Further, strain MANF2 growing under mild stress of M. piperita L. i.e. stressed strain (SS) was tested for its prime functional properties using standard methodologies and compared with the control strain (CS). The SS culture showed increased growth with respect to the CS culture at regular interval of time. A significant (P