The Prognostic Significance of Soluble Urokinase Plasminogen Activator Receptor in Acute Myeloid Leukemia
- Resource Type
- article
- Authors
- Nergiz Erkut; Ahmet Menteşe; Hasan Mücait Özbaş; Nilay Ermantaş; Ayşegül Sümer; Asım Örem; Mehmet Sönmez
- Source
- Turkish Journal of Hematology, Vol 33, Iss 2, Pp 135-140 (2016)
- Subject
- soluble urokinase plasminogen activator receptor
acute myeloid leukemia
prognosis
Diseases of the blood and blood-forming organs
RC633-647.5
- Language
- English
- ISSN
- 1308-5263
INTRODUCTION: The soluble urokinase plasminogen activator receptor (suPAR) is a soluble form of the urokinase plasminogen activator receptor expressed in various immune and cancer cells. The levels of suPAR have been demonstrated to correlate with prognosis in various cancers. This study was intended to investigate serum suPAR levels and their effect on prognosis in patients with acute myeloid leukemia (AML). METHODS: Thirty newly diagnosed patients with AML and 29 healthy individuals were enrolled. Serum suPAR levels were analyzed by enzyme-linked immunosorbent assay. RESULTS: Serum suPAR levels were significantly higher in patients with AML than in healthy individuals (9+-5.9 ng/mL and 2.4+-1.4 ng/mL, respectively; p