Significance of OCT3/4 and SOX2 antigens expression by leukemic blast cells in adult acute leukemia
- Resource Type
- article
- Authors
- Salah Aref; Omnyia Khaled; Nadia El Menshawy; Emad Azmy; Mohamed Aref; Osama Salama; Nada Khaled
- Source
- Journal of the Egyptian National Cancer Institute, Vol 36, Iss 1, Pp 1-14 (2024)
- Subject
- AML
ALL
SOX2
OCT3/4
Outcome
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
- Language
- English
- ISSN
- 2589-0409
Abstract Objective This study aimed to address the prognostic impact of SOX2 and OCT3/4 expression on adult acute leukemia patients’ outcomes. Methods SOX2 and OCT3/4 expression by blast cells were evaluated by flow cytometry in 80 acute leukemia patients and 8 healthy controls. Results Baseline SOX2 and OCT3/4 expression were significantly higher in both ALL (P =