Objective: To determine the efficacy of Lidocaine administration before removal of cross-clamp on prevention of Ventricular Fibrillation (VF) in patients who underwent Coronary Artery Bypass Graft (CABG). Study Design: Quasi-experimental study. Place and Duration of Study: Department of Cardiothoracic Anesthesia, Army Cardiac Center, Lahore Pakistan, from Sep 2021 to Mar 2022. Methodology: One hundred and sixty-two patients were selected non-randomly via consecutive sampling. Patients were divided into two groups i.e., Control and Lidocaine group. Patients of control group were given intravenous Normal Saline while patients in Lidocaine group were given intravenous 2% Lidocaine in dose of 1mg/kg just before release of aortic cross clamp. Main outcome variable was frequency of Ventricular Fibrillation after removal of cross-clamp whereas bypass time, cross-clamp time, Mean Arterial Pressure (MAP) after cardiopulmonary bypass were noted for comparison purpose. Chisquare and t-test were used to compare frequency and mean differences of study variables among study groups. p-value