2D Representation of Transcriptomes by t-SNE Exposes Relatedness between Human Tissues.
- Resource Type
- article
- Authors
- Erdogan Taskesen; Marcel J T Reinders
- Source
- PLoS ONE, Vol 11, Iss 2, p e0149853 (2016)
- Subject
- Medicine
Science
- Language
- English
- ISSN
- 1932-6203
The GTEx Consortium reported that hierarchical clustering of RNA profiles from 25 unique tissue types among 1641 individuals accurately distinguished the tissue types, but a multidimensional scaling failed to generate a 2D projection of the data that separates tissue-subtypes. In this study we show that a projection by t-Distributed Stochastic Neighbor Embedding is in line with the cluster analysis which allows a more detailed examination and visualization of human tissue relationships.