Introduction Smoking and other forms of tobacco consumption are considered the single most important cause of preventable morbidity and premature mortality worldwide. Within EUREST-RISE, an integrated series of research studies are proposed that will facilitate the training of researchers to examine tobacco product systems, their mechanisms and purpose, and interactions between key design characteristics and their assessment in populations of users. Material and Methods EUREST-RISE is a Marie Sklodowska Curie Action (MSCA under Grant Agreement (Number:101008139) currently in its first phase of implementation. Interdisciplinary knowledge transfer will be reached through the intersectoral secondment of researchers and their re-integration to their home institution, within the context of specific research objectives addressed within tasks of each WP. Results The expected results of EUREST-RISE aim to create a cohort of scholars with cutting-edge hands-on training on European tobacco product regulatory science by providing a unique framework of exchange on common research and innovation projects within three areas: A) knowledge exchange on the use of large data bases on responding to tobacco control challenges from the product level or the population level perspective including EU Common Entry Gate product-level data and European secondary population-based datasets B) provide training and research on the implementation of sensory and chemical analyses for the assessment of flavours in tobacco products, heated tobacco and e-cigarettes C) train researchers in advocacy activities and policy integration, facilitate training in peer to peer communication, and training on communication to media and the general public. Conclusions The EUREST-RISE project is expected to establish a network of excellence on European tobacco product regulatory science.