Introduction: Proton Pump Inhibitors (PPIs) are one of the commonly prescribed drugs for peptic ulcer. It has been reported that 25% to 70% of prescriptions do not have proper indication. Recently these drugs are linked with increased incidence of kidney disease. Aim: The present study was conducted to assess the renal parameters in patients on PPI and to correlate it with the duration of treatment and Chronic Kidney Disease (CKD). Materials and Methods: A prospective observational study was carried out among 30 control and 30 test participants. Subjects were enrolled according to inclusion and exclusion criteria. After getting written informed consent, demographic and medication details were recorded. Blood sample was collected for estimation of serum creatinine and Blood Urea Nitrogen (BUN). Estimated Glomerular Filtration Rate (eGFR) was calculated based on serum creatinine levels. Demographic data, medication details and eGFR were expressed as percentage and renal parameters analysed by ANOVA and unpaired t-test. A p