Asthma is a chronic airway inflammatory disease characterized by wheezing, coughing, and tightness in the chest due to airway obstruction. Asthma attacks has variation from mild to severe and can even be fatal or life-threatening (Rai and Artana, 2016). ATC / DDD system means the evaluation methods of the drug use to improve the quality of the use of drug. This study aims to determine the quantity of the use of antiasma’s drug in acute asthma attack patients at RS Paru Respira Yogyakarta in 2016 by the ATC/DDD method. This study was an observational study with retrospective data collection in 2016. The data analysis was done by calculating the percentage of the quantity of drug use by Defined Daily Dose (DDD) per 1000 KPRJ. The result was found that there were 82 patients with inclusion criteria of 129 cases in RS Paru Respira Yogyakarta in 2016. There are 62,20% women and 37,80% men. Age characteristics of 36-45 years old more frequently got acute attacks of asthma (52,40%) compared with the age of 26-35 years amount of 47.60%. The quantity evaluation of antiasma usage in the acute attack asthma patients was formoterol 70.7 / 1000 KPRJ higher than Hbr phenoterol of 0.02 / 1000 KPRJ.