The co-treatment of rosuvastatin with dapagliflozin synergistically inhibited apoptosis via activating the PI3K/AKt/mTOR signaling pathway in myocardial ischemia/reperfusion injury rats
- Resource Type
- article
- Authors
- Gong Lei; Wang Xuyang; Pan Jinyu; Zhang Mingjun; Liu Dian; Liu Ming; Li Li; An Fengshuang
- Source
- Open Medicine, Vol 16, Iss 1, Pp 047-057 (2020)
- Subject
- rosuvastatin
dapagliflozin
apoptosis
pi3k/akt/mtor
ischemia/reperfusion
Medicine
- Language
- English
- ISSN
- 2391-5463
The purpose of the present study was to evaluate the role of co-treatment of rosuvastatin (RSV) and dapagliflozin (DGZ) preconditioning in myocardium ischemia/reperfusion (I/R) injury and to further investigate the underlying mechanism.