Molecular imaging of fibroblast activation in multiple non-ischemic cardiomyopathies
- Resource Type
- article
- Authors
- Jingnan Wang; Li Huo; Xue Lin; Ligang Fang; Marcus Hacker; Na Niu; Xiang Li
- Source
- EJNMMI Research, Vol 13, Iss 1, Pp 1-6 (2023)
- Subject
- 68Ga-FAPI-04
PET imaging
Non-ischemic cardiomyopathy
Medical physics. Medical radiology. Nuclear medicine
R895-920
- Language
- English
- ISSN
- 2191-219X
Abstract Background This pilot study is aimed to perform a pilot visualization study to investigate in vivo fibroblast activation in non-ischemic cardiomyopathies by 68Ga-FAPI-04 PET/CT. Methods Twenty-nine consecutive patients with symptomatic non-ischemic cardiomyopathies who underwent 68Ga-FAPI-04 PET/CT were prospectively recruited. Clinical characteristics and echocardiographic parameters were recorded. Cardiac uptake was quantified by standardized uptake values (SUVmax , SUVmean, SUVR) and left ventricular metabolism volume. The relationship between 68Ga-FAPI-04 uptake with clinical and echocardiography parameters was investigated. Results Heterogeneous 68Ga-FAPI-04 uptake was observed in different subtypes of non-ischemic cardiomyopathies. Twenty-two (75.9%) patients showed elevated 68Ga-FAPI-04 uptake in the left ventricle, and 10 (34.5%) patients also showed slightly diffuse elevated uptake in the right ventricle. Cardiac uptake values were significantly correlated with enlarged ventricular volume evaluated by echocardiography. Conclusion FAPI PET/CT presents a potential value for in vivo visualization and quantification of fibroblast activation on the molecular level. Further study is warranted for investigating the theranostic and prognostic value of elevated FAP signal.