Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition
- Resource Type
- article
- Authors
- Leyuan Xu; Jiankan Guo; Dennis G. Moledina; Lloyd G. Cantley
- Source
- Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
- Subject
- Science
- Language
- English
- ISSN
- 2041-1723
Acute kidney injury can lead to chronic kidney disease. Here the authors show that the transition is related to a macrophage-mediated second wave of inflammatory cells that promote late tubule injury, dedifferentiation and fibrosis. Suppressing this second wave reduced tubular loss and kidney atrophy.