Identification and functional validation of HLA-C as a potential gene involved in colorectal cancer in the Korean population
- Resource Type
- article
- Authors
- Eun Bi Lim; Ho-Suk Oh; Kang Chang Kim; Moon-Ho Kim; Young Jin Kim; Bong Jo Kim; Chu Won Nho; Yoon Shin Cho
- Source
- BMC Genomics, Vol 23, Iss 1, Pp 1-12 (2022)
- Subject
- Colorectal cancer
Exome array association analysis
Functional validation
RNA sequencing
Biotechnology
TP248.13-248.65
Genetics
QH426-470
- Language
- English
- ISSN
- 1471-2164
Abstract Background Colorectal cancer (CRC) is the third most common cancer worldwide and is influenced by environmental and genetic factors. Although numerous genetic loci for CRC have been identified, the overall understanding of the genetic factors is yet to be elucidated. We sought to discover new genes involved in CRC applying genetic association analysis and functional study. Results We conducted exome array analysis on 194 CRC and 600 control subjects for discovering new candidate CRC genes. Fisher’s exact test detected one exome-wide significant functional locus for CRC on SMCO1 (P