The facile synthesis of an iron-based metal-organic framework, MIL-100(Fe) has been successfully conducted via a heatless water-based technique. The unique features have been evaluated with respect to the X-ray diffraction, field emission scanning electron microscopy, nitrogen adsorption-desorption analysis, Fourier transform infrared spectroscopy, and zero point of charge measurement. The adsorptive potential was examined using the cationic (methylene blue, MB) and anionic (naproxen, NPX) water pollutants. The synthesized MIL-100(Fe) sample, MIL-100(FeSO4), owned a crystalline microporous-mesoporous structure, with a large BET surface area of 1984 m2/g and total pore volume of 1.096 cm3/g. The equilibrium data best conformed to the Langmuir-Freundlich isotherm and pseudo-second order kinetic model, with the maximum adsorption capacity for MB and NPX of 568.1 mg/g and 148.8 mg/g, respectively. Thermodynamic analysis revealed the favorable energetics (ΔG 0), endothermic (ΔH > 0 for MB) and exothermic nature (ΔH