Controlled release of dexamethasone from fibrin sealant for intratympanic administration in inner ear therapy
- Resource Type
- article
- Authors
- Jing Zou
- Source
- Journal of Otology, Vol 19, Iss 1, Pp 55-58 (2024)
- Subject
- Intratympanic drug delivery
Controlled release
Corticosteroids
Meniere's disease
Sudden sensorineural hearing loss
Otorhinolaryngology
RF1-547
- Language
- English
- ISSN
- 1672-2930
The aim of the present work was to show the sustainability of fibrin sealant in releasing dexamethasone and adjust the protocol for clinical application of the novel method in the treatment of Meniere's disease (MD) and sudden sensorineural hearing loss (SSHL). Gelation occurred shortly after mixing dexamethasone-containing fibrinogen with thrombin. Dexamethasone was constantly released for at least 16 d at a stable level after 7 d in protocol 1 (low-dose), while it was robustly released within 4 d and slowed afterward until 10 d in protocol 2 (high-dose). There were significant differences among the time points in Protocol 2 (p