Exon Array Analysis to Identify Diethyl-nitrosamine Differentially Regulated and Alternately Spliced Genes in Early Liver Carcinogenesis in the Transgenic Mouse ATT-myc Model
- Resource Type
- article
- Authors
- Mahmoud M. Elalfy; Jürgen Borlak
- Source
- SciMedicine Journal, Vol 3, Iss 2, Pp 138-152 (2021)
- Subject
- n-diethylnitrosamine (ndea)
transgenic
non-transgenic
att-myc mouse model of liver cancer
exon array gene up-regulation
the spliced genes genes.
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Public aspects of medicine
RA1-1270
- Language
- English
- ISSN
- 2704-9833
2021-0302
Objectives: To identify the regulated genes or the spliced genes of diethylnitorsamine (NDEA) in ATT-myc mice versus control group. Methods: We analysed the 9 hybridizations on the MouseExon10ST array of NDEA treatments and control non- transgenic by application of a mixed model analysis of variance. Results: The 907 genes had regulated significantly between the groups and 916 genes had regulated with a significant exon-group interaction among of them 150 genes had regulated with both gene and possible splicing differences (p