The establishment of the prestressed cable loss prediction model is a difficult problem faced by the popularization and use. This article aims at the problem of the loss of anchor cable prestress over time in the soil-rock dual-structure slope. We relied on the soil-rock dual-structure slope treatment project of section K5 + 220-K5 + 770 of Jiangwen Expressway and monitored the prestress loss of the anchor cable in the slope through the anchor cable meter with built-in vibrating wire sensor. Using regression analysis and segmented modelling methods, we established a comprehensive mathematical improvement model, analyzed the applicability of the improved model, and obtained the error range, 0.04%–8.9%. This work offers a new approach for predicting anchor cable prestress loss, which has certain practical value for the use of prestressed anchor cables.