Genetic heterogeneity during breast cancer progression in young patients
- Resource Type
- article
- Authors
- Kanako Hagio; Kanako C. Hatanaka; Toraji Amano; Yoshihiro Matsuno; Yutaka Hatanaka; Hiroko Yamashita
- Source
- Breast, Vol 60, Iss , Pp 206-213 (2021)
- Subject
- Breast cancer
Ductal carcinoma in situ
Invasive carcinoma
Heterogeneity
Targeted sequencing
Young women
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
- Language
- English
- ISSN
- 1532-3080
Background: Because a number of years may be required for normal cells to develop into carcinoma, genes involved in tumorigenesis and progression might differ among breast cancers in young women and those in older women. The present study sought to analyze subclonality during breast cancer evolution as well as diversity within each individual in our young patients’ cohort. Methods: A total of 13 women aged