Serum N-terminal pro-B-type natriuretic peptide and cystatin C for acute kidney injury detection in critically ill adults in China: a prospective, observational study
- Resource Type
- article
- Authors
- Jia Deng; Ying Li; Jing Xu; Linling He; Yufan Liang; Linhui Hu; Heng Fang; Chunbo Chen
- Source
- BMJ Open, Vol 13, Iss 1 (2023)
- Subject
- Medicine
- Language
- English
- ISSN
- 2044-6055
Objective Serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cystatin C (sCysC) are available clinically and beneficial in diagnosing acute kidney injury (AKI). Our purpose is to identify the performance of their combined diagnosis for AKI in critically ill patients.Design A prospectively recruited, observational study was performed.Setting Adults admitted to the intensive care unit of a tertiary hospital in China.Participants A total of 1222 critically ill patients were enrolled in the study.Main outcome measures To identify the performance of the combined diagnosis of serum NT-proBNP and sCysC for AKI in critically ill patients. The area under the receiver operating characteristic curve (AUC-ROC), category-free net reclassification index (NRI) and incremental discrimination improvement (IDI) were utilised for comparing the discriminative powers of a combined and single biomarker adjusted model of clinical variables enriched with NT-proBNP and sCysC for AKI.Results AKI was detected in 256 out of 1222 included patients (20.9%). AUC-ROC for NT-proBNP and sCysC to detect AKI had a significantly higher accuracy than any individual biomarker (p