Does a steroid dementia syndrome really exist? A brief narrative review of what the literature highlights about the relationship between glucocorticoids and cognition
- Resource Type
- article
- Authors
- Ciro Manzo; Alberto Castagna; Carmen Ruberto; Giovanni Ruotolo
- Source
- Geriatric Care, Vol 8, Iss 3 (2023)
- Subject
- Steroid dementia syndrome
Cognitive impairment
Dementia
Glucocorticoids
Adverse drug reaction
Geriatrics
RC952-954.6
- Language
- English
- ISSN
- 2465-1109
2465-1397
Glucocorticoids (GCs) may cause cognitive impairment through complex pathways involving specific receptors. In the human brain, hippocampal CA1 neurons exhibit the highest level of GCs receptors. Even the elderly expressed these receptors. The purpose of this brief review is to concentrate on the relationship between GCs and cognition in order to discuss the effects of the so-called steroid dementia in routine clinical practice.