LOX-1: Implications in atherosclerosis and myocardial ischemia
- Resource Type
- article
- Authors
- Tanya Sharma; Francesco Romeo; Jawahar L. Mehta
- Source
- EXCLI Journal : Experimental and Clinical Sciences, Vol 21, Pp 273-278 (2022)
- Subject
- atherosclerosis
myocardial ischemia
oxidized-ldl
lox-1
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Biology (General)
QH301-705.5
- Language
- English
- ISSN
- 1611-2156
Understanding the pathophysiology of atherosclerosis is fundamental to the practice of cardiovascular medicine. Atherosclerosis is a multi-step cascade of accumulation of lipids and downstream changes that lead to a fibro-fatty plaque formation in the arterial intima. Multiple biochemical stimuli, cellular receptors and intra-cellular signals are implicated in this complex mechanism. Lectin-type oxidized LDL receptor-1 or LOX-1 is a type II membrane glycoprotein receptor which has emerged as an important effector of atherosclerosis. Hence, LOX-1 modification and its clinical consequences are of much interest in recent times.