Successful Treatment of Paradoxical Psoriasis with IL 17 Inhibition: Case Reports
- Resource Type
- article
- Authors
- Gamze Gül Güleç; İlknur Aktaş; Feyza Ünlü Özkan; Nurdan Yurt; Eylem Emel Arıkan
- Source
- Boğaziçi Tıp Dergisi, Vol 7, Iss 1, Pp 34-37 (2020)
- Subject
- anti-tnf
il17 inhibition
paradoxical psoriasis
secukinumab.
Medicine
- Language
- English
Turkish
- ISSN
- 2149-0287
Paradoxical psoriasis (PPs) is new-onset psoriatic skin lesions or worsening of the existing psoriatic skin lesions during anti-TNF therapy. PPs occurs in 2-5% of patients using anti TNF drugs (1). It is a class effect of anti-TNF agents rather than a drug effect and has been observed with all diseases for which TNF-a inhibitors are indicated (2). The time between the starting treatment and the appearance of lesions can range from a few days to years. Discontinuation of anti-TNF therapy, replacement of biological agents, or continued adjuvant therapy are among the treatment options. Inhibition of IL17 can lead to a decrease in PPs and rheumatic disease activity. We aimed to discuss the treatment process and secukinumab in three cases in PPs and to discuss the remission with IL-17 inhibition.