Intramuscular Short-term ACTH Test for the Determination of Adrenal Function in Children: Safe, Effective and Reliable
- Resource Type
- article
- Authors
- Elif Özsu; Zeynep Şıklar; Esra Bilici; Ayşegül Ceran; Rukiye Uyanık; Tuğba Çetin; Zehra Aycan; Merih Berberoğlu
- Source
- JCRPE, Vol 12, Iss 3, Pp 241-247 (2020)
- Subject
- adrenal insufficiency
intramuscular acth
childhood
reliability
Pediatrics
RJ1-570
Diseases of the endocrine glands. Clinical endocrinology
RC648-665
- Language
- English
- ISSN
- 1308-5727
1308-5735
Objective:Standard short adrenocorticotropic hormone (ACTH) stimulation test (SST) has traditionally been used for assessing adrenal gland fuction by intravenous (iv) application. However the iv form is not readily available in all countries, including Turkey. The aim of this study was to evaluate the effectiveness of the intramuscular (im) SST.Methods:Patients underwent im SST with suspected adrenal insufficiency (AI) and hyperandrogenism. The SSTs were done with 250 mcg ACTH (Synacthen Depot ampul, concentration 1 mg/mL). The cases were divided into two groups: suspected AI (group 1 n=87); and hyperandrogenism group (group 2 n=124). Definite AI was defined as peak cortisol