Introduction and Objective: There are conflicting data on the prevalence of cardiovascular risk factors in coronary artery ectasia (CAE). It is unclear whether CAE is associated with high-sensitivity C-reactive protein (hs-CRP) and gamma glutamyltransferase (GGT). We therefore investigated major cardiovascular risk factors, serum GGT and hs-CRP levels in a large population of patients with CAE. Methods: A total of 167 patients with isolated CAE and 150 controls with normal coronary arteries were selected from 10 505 patients undergoing coronary angiography. Serum GGT and hs-CRP levels were evaluated in addition to cardiovascular risk factors including family history, obesity, smoking, diabetes, hypertension and hyperlipidemia. Results: Hypertension and obesity were slightly more prevalent in CAE patients than in controls, whereas diabetes was slightly less frequent in CAE patients. Other risk factors were similar. Serum GGT (22 [17–42] vs. 16 [13–21] U/l, p=0.001) and hs-CRP (2.9 [1.9–3.6] vs. 1.4 [1.1–1.8] mg/l, p=0.001) levels were higher in CAE patients than in controls. The presence of CAE was independently associated with diabetes (OR: 0.44, 95% CI: 0.20–0.95, p=0.04), obesity (OR: 2.84, 95% CI: 1.07–7.56, p=0.04), GGT (OR: 1.08, 95% CI: 1.03–1.12, p=0.001) and hs-CRP levels (OR: 3.1, 95% CI: 2.1–4.6, p=0.001). In addition, GGT and hs-CRP levels were higher in diffuse and multivessel ectasia subgroups than focal and single-vessel ectasia subgroups (each p