Altered aspects of anxiety-related behavior in kisspeptin receptor-deleted male mice
- Resource Type
- article
- Authors
- Sarah Delmas; Robert Porteous; Dave H. Bergin; Allan E. Herbison
- Source
- Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
- Subject
- Medicine
Science
- Language
- English
- ISSN
- 2045-2322
Abstract The roles of kisspeptin signaling outside the hypothalamus in the brain are unknown. We examined here the impact of Kiss1r-deletion on hippocampus-related behaviors of anxiety and spatial learning in adult male mice using two mouse models. In the first, global Kiss1r-null and control mice were gonadectomized (GDX KISS1R-KO). In the second, KISS1R signalling was rescued selectively in gonadotropin-releasing hormone neurons to generate Kiss1r-null mice with normal testosterone levels (intact KISS1R-KO). Intact KISS1R-KO rescue mice were found to spend twice as much time in the open arms of the elevated plus maze (EPM) compared to controls (P