Late gadolinium enhancement entropy as a new measure of myocardial tissue heterogeneity for prediction of adverse cardiac events in patients with hypertrophic cardiomyopathy
- Resource Type
- article
- Authors
- Zi-Yi Gu; Yu-Fan Qian; Bing-Hua Chen; Chong-Wen Wu; Lei Zhao; Song Xue; Lian-Ming Wu; Yong-Yi Wang
- Source
- Insights into Imaging, Vol 14, Iss 1, Pp 1-10 (2023)
- Subject
- Magnetic resonance imaging
Prognosis
Hypertrophic cardiomyopathy
Medical physics. Medical radiology. Nuclear medicine
R895-920
- Language
- English
- ISSN
- 1869-4101
Abstract Objectives Entropy is a new late gadolinium enhanced (LGE) cardiac magnetic resonance (CMR)–derived parameter that is independent of signal intensity thresholds. Entropy can be used to measure myocardial tissue heterogeneity by comparing full pixel points of tissue images. This study investigated the incremental prognostic value of left ventricular (LV) entropy in patients with hypertrophic cardiomyopathy (HCM). Methods This study enrolled 337 participants with HCM who underwent 3.0-T CMR. The LV entropy was obtained by calculating the probability distribution of the LV myocardial pixel signal intensities of the LGE sequence. Patients who underwent CMR imaging were followed up for endpoints. The primary endpoint was defined as readmission to the hospital owing to heart failure. The secondary endpoint was the composite of the primary endpoint, sudden cardiac death and non-cardiovascular death. Results During the median follow-up of 24 months ± 13 (standard deviation), 43 patients who reached the primary and secondary endpoints had a higher entropy (6.20 ± 0.45, p